The present study aimed to investigate the effectiveness of a Qur’an-based positive psychology educational program on mental health.This quasi-experimental research was conducted using a pretest–posttest design with a one-month follow-up and a control group. The statistical population consisted of male undergraduate student-teachers at Farhangian University of Tehran in the 2023–2024 academic year. From this population, 34 eligible participants were purposefully selected and randomly assigned to experimental and control groups (17 in each). Data were collected using the General Health Questionnaire (GHQ-28). The experimental group participated in ten 90-minute sessions of Qur’an-based positive psychology training. Data analysis, performed through repeated-measures ANOVA in SPSS-26, revealed that the intervention led to a significant improvement in the overall mental health score and a meaningful reduction in somatic symptoms, anxiety and insomnia, social dysfunction, and depressive symptoms in the experimental group compared to the control group (P<0.001). These positive effects were sustained at the one-month follow-up. The findings indicate that Qur’an-based positive psychology training, as a localized and spiritually consistent intervention, holds considerable potential to enhance mental health and reduce psychological disorders among student-teachers. Moreover, it can serve as an effective complementary approach in mental health interventions within similar cultural and religious contexts.